Daily business briefing Why are antibiotics so important? Without them, modern medicine would not be possible. Arguably the most important factor in the year jump in American life expectancy in the 20th century, these "wonder drugs" allow us to fight the whole gamut of bacterial illness, from everyday ear infections to diseases such as syphilis, typhoid, and tuberculosis that used to kill millions of people. Their discovery about years ago also revolutionized the world of surgery:
Acquisition significantly accelerates development of new products targeting antibiotic-resistant pathogens and microbiome indications.
Terms of the deal are undisclosed. This DNA-shredding technology is the most potent mechanism of action for driving programmed cell death using CRISPR and is functionally distinct from the better-known Cas9 systems used in gene editing.
An Emerging Global Crisis Phage have been used to kill bacteria for more than years but fell out of favor when highly effective antibiotics were developed in the midth century.
However, abuse of antibiotics in agriculture and their over-prescription in medicine is creating a global crisis through the rapid emergence of antibiotic resistance. Scientists around the world are sounding the alarm that we are entering a post-antibiotic era in which all currently available antibiotics will soon be ineffective.
This crisis has renewed interest in phage therapeutics. This advancement in technology is crucial, as many large pharmaceutical companies have exited the antibiotics market due to the time, prohibitive costs, and risk related to developing new antibiotics.
We also expect to complete clinical development in less than half the time of traditional antibiotics. Nick Conley, co-founder and chief science officer of EpiBiome.
In addition to strengthening its phage discovery platform, this transaction adds additional assets to the Locus development pipeline including a Staphylococcus aureus program and assets targeting other ESKAPE pathogens, which are the leading causes of nosocomial infections globally.
Its novel approach leverages an adaptive immune system present in many bacteria called the CRISPR-Cas system to engineer bacteriophages that precisely kill target bacteria while leaving non-targeted beneficial bacteria unharmed.
With venture capital funding from ARTIS Ventures, Tencent Holdings, Abstract Ventures and others, Locus is rapidly moving its lead programs into clinical development for infectious disease and microbiome indications, with the first clinical trials on track to begin in For more information about Locus visit https: About EpiBiome Founded in in the San Francisco Bay Area, EpiBiome developed a high-throughput automated phage discovery platform integrating next-generation sequencing, bioinformatics, machine learning, and directed evolution technologies to rapidly create phage cocktails targeting pathogens with high unmet medical need.Tag: Post-Antibiotic Era.
Are We Entering a Post-Antibiotic Era? AnonWatcher-January 23, 0. Anonymous Wear. Popular Posts. Student’s 9/11 Chilling Footage Taken From Her Dorm Room Is Going Viral Again; We'll assume you're ok with this, but you can opt-out if you wish.
With the World Health Organization (WHO) warning that we are on the cusp of entering a "post-antibiotic era," the race is on to find new antibiotics that can combat drug-resistant infections.
INFECTION PREVENTION AND CONTROL: OVERVIEW OF THE NEW CMS RULES & SURVEY PROCESS Infection Prevention and Control and Antibiotic Stewardship. Final Rule-Implementation Time Frames experts agree we are entering a post-antibiotic era. Looking at the Future: Is This the Post-Antibiotic Era?
The problem of the explosive growth in the development of antimicrobial resistance in the last two decades has only been made worse by a significant and steady decrease in the number of approvals of new antibacterials in the last 10–15 years . Scientists around the world are sounding the alarm that we are entering a post-antibiotic era in which all currently available antibiotics will soon be ineffective.
This crisis has renewed. The End of the Antibiotic Era: What You Need to Know About Bacterial Resistance “All the key players are now in place to make the post-antibiotic world a reality.” We .